VaRi Bioscience welcomes your interest in our company, our products, and our progress. VaRi Bioscience founders published work is falling in different categories. On this page you will find a small selection of publications they were involved.
Vaginal Ring Technology
Koutsamanis, I., Eder, S., Baretta, M., Witschnigg, A., Nickisch, K., Friedrich, M., Eggenreich, K., Roblegg, E., (2019) Formulation and processability screening of the rational design of ethylene-vinyl acetate based intra-vaginal rings, Int J Pharm,564:90-97
Eder, S., Beretta, M., Witschnigg, A., Koutsamanis, I., Eggenreich, K., Khinast, J.G., Koscher, G., Paudel, A., Nickisch, K., Friedrich, M., Froehlich, E., Roblegg, E., (2017) Establishment of a Molding Procedure to Facilitate Formulation Development for Co-extrudates., AAPS PharmSciTech. Nov;18(8):2971-2976
Extenbrink, A., Eggenreich, K., Eder, S., Mohr, S., Nickisch, K., Klein, S. (2017) Development and evaluation of accelerated drug release testing methods for a matrix-type intravaginal ring, European Journal of Pharmaceutics and Biopharmaceutics 110 1-12.
van Laarhoven, J.A.H., Kruft, M.A.B., Vromans, H., (2002) In vitro release properties of etonogestrel and ethinyl estradiol from a contraceptive vaginal ring, International Journal of Pharmaceutics, Volume 232, Issues 1–2, Pages 163-173
van Laarhoven, J.A.H., Kruft, M.A.B., Vromans, H., (2002) Effect of supersaturation and crystallization phenomena on the release properties of a controlled release device based on EVA copolymer, Journal of Controlled Release, Volume 82, Issues 2–3, Pages 309-317
Clinical Trials
Donath, F., Hoffmann, L., Todorova-Sanjari, M., Wedemeyer, R., Warnke, A. & Klaus Nickisch, K. (2021) Intravaginal Tolterodine Formulation Intended for Overactive Bladder Treatment—Results of a Pharmacokinetic Phase I Pilot Study in Healthy, Postmenopausal Women, Clinical Pharmacology in Drug Development, 0(0) 1–11, The American College of Clinical Pharmacology, DOI: 10.1002/cpdd.968
Antunes, N.J., Oliveira Filho, R.V., Ilha, J.O., Moreno, R.A., Wedemeyer, R., Warnke, A., De Nucci, Br J., (2021) Single-Dose pharmacokinetics and pharmacodynamic assesment of oestriol and trimegestone containi ng vaginal rings in healthy women with childbearing potential, The European Journal of Contraception & Reproductive Health care, 26 (3) 184-194
Duijkers, I., Klipping, C., Draeger, C., Schug, B.S., Dax, A., Friedrich, M., Nickisch, K., (2020) Ovulation inhibition with a new vaginal ring containing trimegestone, Contraception 102(4) 2020 237-242
Raimundo Vieira de Oliveira Filho, Natalícia de Jesus Antune; Ronilson Agnaldo Moreno; Gilberto De Nucci, (2019) A randomized, open-label trial to evaluate the pharmacokinetics and pharmacodynamics of 3 dosages of estriol after continuous vaginal administration for 21 days in healthy post-menopausal women, Br J. Clin Pharmacol.; 85(3): 551-562
Process Chemistry
Westermann, J., Schneider, M., Platzeck, J., Petrov, O., (2007) Practical synthesis of a heterocyclic immunosuppressive vitamin D analogue, Org. Process Res. Dev. 11, 200–205
Schmitt-Willich, H., Brehm, M., Ewers, Ch. L. J., Michl, G.; Mueller-Fahrnow, A., Petrov, O., Platzek, J., Raduechel, B., Suelzle, D. (1999) Synthesis and Physicochemical Characterization of a New Gadolinium Chelate: The Liver-Specific Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA. Inorganic Chemistry, 38(6), 1134-1144.
Enev, V., Petrov, O., Neh, H., Nickisch, K. (1997) Studies towards a total synthesis of the antiprogestine onapristone. Tetrahedron, 53(40), 13709-13718
Petrov, O., Ognyanov, I. (1991) An approach to the synthesis of novel 11-hydroxyartemisinin derivatives. Collection of Czechoslovak Chemical Communications, 56(5), 1037-41.
Ognyanov, V., Petrov, O. Tikholov, E. Mollov, N. (1989) Synthesis of gossypol analogs. Helvetica Chimica Acta, 72(2), 353-60
Business Strategy
Bode-Greuel, K. & Nickisch, K. (2014) Deciding between biobetter versus biosimilar development options based on net present value calculations. Journal of Commercial Biotechnology. 20 (2). p.21-31
Nickisch K, Greuel J. & Bode-Greuel K. (2009) How can pharmaceutical and biotechnology companies maintain a high profitability?, Journal of Commercial Biotechnology 15, 309 – 323
Bode-Greuel, K. & Nickisch, K. (2008) Value-driven project and portfolio management in the pharmaceutical industry: Drug discovery versus drug development – Commonalities and differences in portfolio management practice. Journal of Commercial Biotechnology. 14 (4). p.307-325
Bode-Greuel, K. & Greuel, J. (2005) Determining the value of drug development candidates and technology platforms. Journal of Commercial Biotechnology. 11 (2). p.155-170
